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9.Lack of cutin cell growth factor - Ⅰ disulfide bond allosteric body and its USES
Source: | Author:pro954f45 | Published time: 2018-10-17 | 193 Views | Share:
    The invention relates to a kind of missing type cutin cell growth factor - Ⅰ disulfide bond allosteric body and its preparation and application, is characterized by the disulfide bond allosteric body contains natural cutin cell growth factor - Ⅰ between 40 and 106 cysteine unnatural disulfide bond structure. The invention using genetic engineering and technical preparation for human recombinant cutin cell growth factor - lack of Ⅰ mutant, through specific disulfide bond matching renaturation method to make forming type missing mutant 17th 83th cysteine and unnatural disulfide bond. The disulfide bond allosteric body has the biological effect of inhibiting the proliferation of fibers and the growth of new blood vessels, which is expected to be developed into a drug for the prevention and treatment of fibrogenic and vascular proliferative diseases.